Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum

Nat Clin Pract Oncol. 2006 May;3(5):281-4; quiz 285. doi: 10.1038/ncponc0482.

Abstract

Background: A 64-year-old woman presented to the emergency room with a 3-month history of intermittent abdominal cramps, accompanied by nausea, vomiting, anorexia, and decreased bowel movements consistent with a partial intestinal obstruction. She had a 12-year history of peptic ulcers, which had been treated with histamine-2 blockers.

Investigations: Physical examination, abdominal X-ray, abdominal CT scan, colonoscopy and assessment of gastrin levels.

Diagnosis: Duodenal neuroendocrine neoplasm showing gastrin expression and stage III (T3N2M0), poorly differentiated adenocarcinoma of the cecum arising from hyperplastic polyposis.

Management: Right-sided hemicolectomy with ileocolonic anastomosis, duodenal resection, leucovorin and 5-fluorouracil chemotherapy, annual colonoscopic surveillance, and polypectomy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma* / diagnosis
  • Adenocarcinoma* / drug therapy
  • Adenocarcinoma* / surgery
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Colectomy
  • Colonic Neoplasms* / diagnosis
  • Colonic Neoplasms* / drug therapy
  • Colonic Neoplasms* / surgery
  • Colonic Polyps* / diagnosis
  • Colonic Polyps* / drug therapy
  • Colonic Polyps* / surgery
  • Diagnosis, Differential
  • Duodenal Neoplasms* / diagnosis
  • Duodenal Neoplasms* / drug therapy
  • Duodenal Neoplasms* / surgery
  • Female
  • Gastrinoma* / diagnosis
  • Gastrinoma* / drug therapy
  • Gastrinoma* / surgery
  • Humans
  • Hyperplasia
  • Middle Aged
  • Neoplasms, Multiple Primary* / diagnosis
  • Neoplasms, Multiple Primary* / drug therapy
  • Neoplasms, Multiple Primary* / surgery
  • Treatment Outcome
  • Zollinger-Ellison Syndrome / diagnosis