Mitochondrial ROS production initiates Abeta1-40-mediated up-regulation of L-type Ca2+ channels during chronic hypoxia

Adv Exp Med Biol. 2006:580:197-201; discussion 351-9. doi: 10.1007/0-387-31311-7_30.

Authors

Ian M Fearon¹, Stephen T Brown, Kristin Hudasek, Jason L Scragg, John P Boyle, Chris Peers

Affiliation

¹ Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK.

PMID: 16683719
DOI: 10.1007/0-387-31311-7_30

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid beta-Peptides / metabolism*
Calcium Channels, L-Type / genetics
Calcium Channels, L-Type / metabolism*
Cell Hypoxia / genetics
Cell Hypoxia / physiology*
Cell Line
Electron Transport Complex I / metabolism
Humans
Mitochondria / metabolism
Peptide Fragments / metabolism*
Reactive Oxygen Species / metabolism
Recombinant Proteins / genetics
Recombinant Proteins / metabolism
Transfection
Up-Regulation

Substances

Amyloid beta-Peptides
Calcium Channels, L-Type
L-type calcium channel alpha(1C)
Peptide Fragments
Reactive Oxygen Species
Recombinant Proteins
amyloid beta-protein (1-40)
Electron Transport Complex I