Abstract
BHC80 is a component of BRAF-HDAC complex (BHC) involved in transcriptional repression of neuron-specific genes in non-neuronal cells. However, BHC80 is present in both neuronal and non-neuronal cells. To explore the physiological importance of BHC80 in vivo, and the precise mechanism underlying neuron-specific gene repression by BHC80, we have produced mutant mice lacking Bhc80. The loss of Bhc80 resulted in neonatal lethality without sucking mother's breast milk sufficiently. Although Bhc80-deficient mice showed no developmental defect in the neuronal and non-neuronal tissues, Bhc80 is indispensable for the survival of neonatal pups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Apoptosis
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Astrocytes / cytology
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Astrocytes / enzymology
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Cell Movement
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Genes, Lethal*
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Histone Deacetylases / genetics
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Histone Deacetylases / metabolism
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Histone Deacetylases / physiology*
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Humans
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Lung / chemistry
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Lung / cytology
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Lung / metabolism
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Male
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Mice
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Mice, Mutant Strains
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Neurons / cytology
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Neurons / enzymology
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Proto-Oncogene Proteins B-raf / metabolism
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Proto-Oncogene Proteins c-raf / genetics
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Proto-Oncogene Proteins c-raf / physiology*
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Synapsins / analysis
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Synapsins / metabolism
Substances
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Phf21a protein, mouse
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Synapsins
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Braf protein, mouse
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Proto-Oncogene Proteins B-raf
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Proto-Oncogene Proteins c-raf
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Histone Deacetylases