Abstract
Authors from Australia describe how interfering with cell survival is increasingly being chosen as a method of developing a treatment strategy for hormone-resistant prostate cancer. The authors show how several developmental drug candidates have preclinical and clinical activity against cell survival proteins, and that these might be worth considering as possible clinical entities in this condition. The commonly stated argument that laparoscopy has advanced the cause of donor nephrectomy in renal transplantation is examined by authors from the UK. They present a review of the published reports and show that the evidence base is poor for drawing a conclusion as to whether laparoscopic or open nephrectomy is best.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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3-Phosphoinositide-Dependent Protein Kinases
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Apoptosis
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Cell Communication
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Cell Survival / drug effects*
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Humans
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Male
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NF-kappa B / metabolism
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Oncogene Protein v-akt / antagonists & inhibitors
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Oncogene Protein v-akt / metabolism
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / pathology
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Protein Kinases / metabolism
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Protein Serine-Threonine Kinases / antagonists & inhibitors
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Protein Serine-Threonine Kinases / metabolism
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Protein-Tyrosine Kinases / metabolism
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Signal Transduction / drug effects
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TOR Serine-Threonine Kinases
Substances
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NF-kappa B
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Proto-Oncogene Proteins c-bcl-2
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Protein Kinases
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MTOR protein, human
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Protein-Tyrosine Kinases
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3-Phosphoinositide-Dependent Protein Kinases
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Oncogene Protein v-akt
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Protein Serine-Threonine Kinases
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TOR Serine-Threonine Kinases