Abstract
The influence of lithium chloride on the proliferation of normal granulocyte-macrophage progenitor cells (CFU-GM) and clonogenic blasts (CFU-L) from patients with acute myeloid leukaemia in the semisolid cultures in vitro was investigated. It was observed that while lithium chloride with the concentration of 2 mmol/l increases the number of CFU-GM colonies, it does not increase the number of CFU-L colonies and clusters. Our studies indicate that lithium salts can be used for the treatment of patients with acute myeloid leukaemia after intensive chemotherapy.
MeSH terms
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Cell Division / drug effects
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Cells, Cultured
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Chlorides / pharmacology*
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Colony-Forming Units Assay
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Granulocytes / cytology
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Granulocytes / drug effects
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Hematopoiesis / drug effects
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / drug effects*
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Humans
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Leukemia, Myeloid, Acute / drug therapy*
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Leukemia, Myeloid, Acute / pathology
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Lithium / pharmacology*
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Lithium Chloride
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Macrophages / cytology
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Macrophages / drug effects
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Neoplastic Stem Cells / drug effects*
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Neoplastic Stem Cells / pathology
Substances
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Chlorides
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Lithium
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Lithium Chloride