Abstract
From Sarcolobus globosus, two rotenoids (villosinol and 6-oxo-6a,12a-dehydrodeguelin), one isoflavone (genistin) and four phenolic glycosides (vanillic acid 4-O-beta-d-glucoside, glucosyringic acid, tachioside and isotachioside) were identified for the first time from this species. Extracts and compounds from S. globosus were evaluated for their DPPH radical scavenging and 15-lipoxygenase (15-LO) inhibitory activities. All tested rotenoids were found to inhibit 15-LO, while they lacked DPPH radical scavenging effect.
MeSH terms
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Apocynaceae*
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Arachidonate 15-Lipoxygenase / drug effects*
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Biphenyl Compounds
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Glycosides / chemistry
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Glycosides / pharmacology
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Humans
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Isoflavones / chemistry
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Isoflavones / pharmacology
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Lipoxygenase Inhibitors
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Phenols / chemistry
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Phenols / pharmacology
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Phytotherapy*
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Picrates / chemistry
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Rotenone / chemistry
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Rotenone / pharmacology
Substances
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Antioxidants
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Biphenyl Compounds
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Enzyme Inhibitors
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Glycosides
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Isoflavones
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Lipoxygenase Inhibitors
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Phenols
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Picrates
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Plant Extracts
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Rotenone
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1,1-diphenyl-2-picrylhydrazyl
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Arachidonate 15-Lipoxygenase