Experimental reduction of portal hypertension by mechanical increase of liver portal flow

N Habib; D Houssin; C Carol; J Cardoso; C Boisseau; Y Calmus; Y Ozier; J Quere; C Wood; N McIntyre

doi:10.1016/0140-6736(91)93334-6

Experimental reduction of portal hypertension by mechanical increase of liver portal flow

Lancet. 1991 Jan 5;337(8732):16-7. doi: 10.1016/0140-6736(91)93334-6.

Authors

N Habib¹, D Houssin, C Carol, J Cardoso, C Boisseau, Y Calmus, Y Ozier, J Quere, C Wood, N McIntyre

Affiliation

¹ Hepatobiliary and Liver Transplantation Unit, Royal Free Hospital, London, UK.

PMID: 1670651
DOI: 10.1016/0140-6736(91)93334-6

Abstract

Studies on the isolated perfused rat liver demonstrated that an increase in portal pressure is associated with an increase in the portal blood flow in normal and in cirrhotic livers. In two pigs with portal hypertension mesenteric portal pressure was lowered by mechanically increasing the liver portal blood flow by means of a balloon pump around the portal vein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Flow Velocity
Hypertension, Portal / etiology
Hypertension, Portal / physiopathology
Hypertension, Portal / therapy*
Liver Circulation*
Liver Cirrhosis, Experimental / complications
Portal Vein / physiopathology*
Rats
Rats, Inbred Strains
Swine