Absence of retroviral sequences in Graves' disease

M Humphrey; J Mosca; J R Baker Jr; J J Drabick; F E Carr; D S Burke; L Wartofsky; Y Y Djuh; K D Burman

doi:10.1016/0140-6736(91)93335-7

Absence of retroviral sequences in Graves' disease

Lancet. 1991 Jan 5;337(8732):17-8. doi: 10.1016/0140-6736(91)93335-7.

Authors

M Humphrey¹, J Mosca, J R Baker Jr, J J Drabick, F E Carr, D S Burke, L Wartofsky, Y Y Djuh, K D Burman

Affiliation

¹ Endocrine-Metabolic Service, Walter Reed Army Medical Center, Washington, DC 20307.

PMID: 1670652
DOI: 10.1016/0140-6736(91)93335-7

Abstract

An earlier report of HIV-1 gene sequences in thyroid cell genomic DNA from patients with Graves' disease prompted use of the polymerase chain reaction technique to identify such sequences in Graves' disease thyroid tissue and in white blood-cells from these patients. We were unable to confirm the existence of HIV-1-related DNA sequences in Graves' specimens.

Publication types

Clinical Trial

MeSH terms

DNA, Viral / analysis*
Graves Disease / genetics
Graves Disease / microbiology*
HIV-1 / genetics*
Humans
Nucleic Acid Hybridization
Polymerase Chain Reaction
Thyroiditis, Autoimmune / genetics
Thyroiditis, Autoimmune / microbiology*

Substances

DNA, Viral