Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal

Trans R Soc Trop Med Hyg. 2006 Nov;100(11):1063-7. doi: 10.1016/j.trstmh.2005.12.011. Epub 2006 May 22.

Abstract

We performed pulsed-field gel electrophoresis (XbaI) on 114 bloodstream isolates of Salmonella enterica serotype Paratyphi A and S. enterica serotype Typhi collected from febrile patients in Kathmandu, Nepal. Of the 56 S. Paratyphi A isolates, 51 (91%) were indistinguishable, which suggests the emergence of a single clone. In contrast, only 21 (36%) of the 58 S. Typhi isolates exhibited a common genotype, which is consistent with endemic disease from multiple sources.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Infective Agents / therapeutic use
  • Communicable Diseases, Emerging / drug therapy
  • Communicable Diseases, Emerging / epidemiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nepal / epidemiology
  • Paratyphoid Fever / drug therapy
  • Paratyphoid Fever / epidemiology*
  • Salmonella paratyphi A / isolation & purification*
  • Typhoid Fever / drug therapy
  • Typhoid Fever / epidemiology*
  • Urban Health

Substances

  • Anti-Infective Agents