Infiltrating orbital astrocytic proliferation associated with congenitally malformed eyes

Ophthalmic Plast Reconstr Surg. 2006 May-Jun;22(3):227-9. doi: 10.1097/01.iop.0000216786.71358.ad.

Abstract

This report describes the clinical and pathologic findings in two adults with orbital infiltration by astrocytic cells associated with congenitally malformed eyes. Both cases had enlarging orbital masses and underwent complete resection. Histopathology revealed proliferation of astrocytes (fibrillary acidic protein-positive) that invaded the orbital tissues. To the best of our knowledge, there are no similar cases in the literature.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Anophthalmos / pathology*
  • Astrocytes / metabolism
  • Astrocytes / pathology*
  • Biomarkers / metabolism
  • Cell Proliferation
  • Glial Fibrillary Acidic Protein / metabolism
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Microphthalmos / pathology*
  • Oculomotor Muscles / pathology
  • Orbital Diseases / diagnosis*
  • Orbital Diseases / metabolism
  • S100 Proteins / metabolism
  • Tomography, X-Ray Computed

Substances

  • Biomarkers
  • Glial Fibrillary Acidic Protein
  • S100 Proteins