Abstract
The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenovirus Early Proteins
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Animals
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Blotting, Southern
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Cell Division
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Cell Line
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Cell Transformation, Neoplastic*
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Gene Expression
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Mice
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Mice, Nude
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Neoplasms, Experimental / genetics
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Oncogene Proteins, Viral / physiology*
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Oncogenes*
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Proto-Oncogene Proteins / genetics*
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Receptor, ErbB-2
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Transfection
Substances
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Adenovirus Early Proteins
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Oncogene Proteins, Viral
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Proto-Oncogene Proteins
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Receptor, ErbB-2