Narcolepsy-cataplexy associated with precocious puberty

Neurology. 2006 May 23;66(10):1577-9. doi: 10.1212/01.wnl.0000216142.21375.71.

Abstract

In children, narcolepsy may be the symptom of a brain lesion or genetic disease. The authors report two cases with severe narcolepsy-cataplexy emerging in childhood in close temporal association with obesity and precocious puberty.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / analysis
  • Benzhydryl Compounds / therapeutic use
  • Cataplexy / complications*
  • Cataplexy / diagnosis
  • Cataplexy / drug therapy
  • Child
  • Creatine / analysis
  • Cyclohexanols / therapeutic use
  • Disorders of Excessive Somnolence / etiology
  • Female
  • Hallucinations / etiology
  • Health Education
  • Humans
  • Hypothalamus / chemistry
  • Hypothalamus / physiopathology*
  • Intracellular Signaling Peptides and Proteins / deficiency
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Male
  • Modafinil
  • Narcolepsy / complications*
  • Narcolepsy / diagnosis
  • Narcolepsy / drug therapy
  • Neuropeptides / deficiency
  • Neuropeptides / physiology*
  • Night Terrors / etiology
  • Obesity / complications
  • Orexins
  • Polysomnography
  • Puberty, Precocious / complications*
  • Puberty, Precocious / physiopathology
  • Television
  • Venlafaxine Hydrochloride

Substances

  • Benzhydryl Compounds
  • Cyclohexanols
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins
  • Aspartic Acid
  • Venlafaxine Hydrochloride
  • N-acetylaspartate
  • Creatine
  • Modafinil