Drug-eluting stents are widely used to prevent restenosis after coronary angioplasty. We here report a case of stent thrombosis within a sirolimus-eluting stent occurring two years after stent implantation, while the patient was on chronic aspirin therapy. The patient presented with acute ST-elevation myocardial infarction and pulmonary oedema; stent thrombosis was successfully treated with coronary angioplasty and deployment of a new coronary stent. This case suggests that long-term follow-up is needed in clinical studies on drug-eluting stents.