Sarcophytonolides E-H, cembranolides from the Hainan soft coral Sarcophyton latum

Rui Jia; Yue-Wei Guo; Ernesto Mollo; Margherita Gavagnin; Guido Cimino

doi:10.1021/np050477u

Sarcophytonolides E-H, cembranolides from the Hainan soft coral Sarcophyton latum

J Nat Prod. 2006 May;69(5):819-22. doi: 10.1021/np050477u.

Authors

Rui Jia¹, Yue-Wei Guo, Ernesto Mollo, Margherita Gavagnin, Guido Cimino

Affiliation

¹ State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Shanghai 201203, People's Republic of China.

PMID: 16724849
DOI: 10.1021/np050477u

Abstract

Four new cembrane diterpenes, sarcophytonolides E-H (1-4), were isolated from the Hainan soft coral Sarcophyton latum. Their structures were elucidated by detailed spectroscopic (IR, MS, 2D NMR) analysis and by comparison with related known compounds. The absolute stereochemistry of sarcophytonolide H (4) was determined by applying the modified Mosher's method.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Diterpenes* / chemistry
Diterpenes* / isolation & purification
Diterpenes* / pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Tumor Cells, Cultured

Substances

Diterpenes