ACE-it: a tool for genome-wide integration of gene dosage and RNA expression data

Wessel N van Wieringen; Jeroen A M Belien; Sjoerd J Vosse; Eskeatnaf M Achame; Bauke Ylstra

doi:10.1093/bioinformatics/btl269

ACE-it: a tool for genome-wide integration of gene dosage and RNA expression data

Bioinformatics. 2006 Aug 1;22(15):1919-20. doi: 10.1093/bioinformatics/btl269. Epub 2006 May 26.

Authors

Wessel N van Wieringen¹, Jeroen A M Belien, Sjoerd J Vosse, Eskeatnaf M Achame, Bauke Ylstra

Affiliation

¹ Department of Mathematics, Vrije Universiteit De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands.

PMID: 16731696
DOI: 10.1093/bioinformatics/btl269

Abstract

Summary: We describe a tool, called ACE-it (Array CGH Expression integration tool). ACE-it links the chromosomal position of the gene dosage measured by array CGH to the genes measured by the expression array. ACE-it uses this link to statistically test whether gene dosage affects RNA expression.

Availability: ACE-it is freely available at http://ibivu.cs.vu.nl/programs/acewww/.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms*
Base Sequence
Chromosome Mapping / methods*
Computer Simulation
Gene Dosage / genetics*
Models, Genetic
Models, Statistical
Molecular Sequence Data
Oligonucleotide Array Sequence Analysis / methods*
RNA / genetics*
Sequence Analysis, RNA / methods*
Software*
Systems Integration

Substances

RNA