A hybrid phosphorus ligand for highly enantioselective asymmetric hydroformylation

J Am Chem Soc. 2006 Jun 7;128(22):7198-202. doi: 10.1021/ja057065s.

Abstract

A new hybrid phosphorus ligand has been prepared starting from chiral NOBIN (2-amino-2'-hydroxy-1,1'-binaphthyl). Excellent enantioselectivities (up to 99% ee) have been achieved in the Rh-catalyzed asymmetric hydroformylations of styrene derivatives and vinyl acetate.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aldehydes / chemical synthesis
  • Aldehydes / chemistry
  • Alkenes / chemistry
  • Carbon Monoxide / chemistry
  • Catalysis
  • Hydrogen / chemistry*
  • Ligands
  • Models, Molecular
  • Molecular Structure
  • Organophosphorus Compounds / chemical synthesis*
  • Organophosphorus Compounds / chemistry
  • Phosphines / chemical synthesis*
  • Phosphines / chemistry
  • Stereoisomerism
  • Styrene / chemistry

Substances

  • Aldehydes
  • Alkenes
  • Ligands
  • Organophosphorus Compounds
  • Phosphines
  • phosphoramidite
  • Styrene
  • Carbon Monoxide
  • Hydrogen
  • phosphine