Medication errors can lead to treatment failure and adverse drug reactions with potentially life-threatening consequences, especially when the patient is fragile or the drug is highly toxic. Both these latter factors are frequent in the cancer setting. Computers can be used to securitize the prescription (through validated protocols), preparation and administration of anticancer drugs, including experimental drugs, as they can store a wealth of information on both the individual patient and the product. We report our experience at Hotel-Dieu Hospital in Paris, where a computerized anticancer drug distribution system has increased treatment safety, provided major cost savings, and allowed nurses to spend more time with their patients.