[Introduction on "case-sibling control design"]

Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Feb;27(2):170-3.
[Article in Chinese]

Abstract

Objective: To introduce the design and statistical methods of case-sibling control design and to analyze the published data.

Methods: Data from an association study between the coronary heart disease and methylenetetrahydrofolate reductase gene C677T polymorphism was analyzed by the sib transmission/disequibrium test (s-TDT) and the sibship disequilibrium (SDT) methods.

Results: Using s-TDT method, Z value was 0.27 with P > 0.05. The result of SDT method showed that chi-square was 0.31 with 1 df, P > 0.05. All results suggested that neither s-TDT nor SDT showed significant difference between the transmitted and untransmitted methylenetetrahydrofolate reductase gene C677T allele distributions.

Conclusion: Case-sibling control design might avoid population stratification by using siblings as controls thus might be used to test association and linkage between genes and disease.

Publication types

  • English Abstract

MeSH terms

  • Case-Control Studies*
  • Chi-Square Distribution
  • Coronary Disease / genetics
  • Epidemiologic Methods
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Linkage
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Polymorphism, Genetic
  • Research Design*
  • Siblings*

Substances

  • Methylenetetrahydrofolate Reductase (NADPH2)