Terpenoids and bisbibenzyls from Chinese liverworts Conocephalum conicum and Dumortiera hirsuta

J Asian Nat Prod Res. 2006 Jan-Mar;8(1-2):187-92. doi: 10.1080/1028602042000325537.

Abstract

Four new monoterpene esters, 2alpha,5beta-dihydroxybornane-2-cinnamate (1), 2alpha,5beta-dihydroxybornane-5-acetyl-2-cinnamate (2), 2alpha,5beta-dihydroxybornane-2-p-hydroxycinnamate (3) and 2alpha,5beta-dihydroxy-bornane-2-cis-p-hydroxycinnamate (4), together with a known compound 3,4-dimethoxystyrene (5) were isolated from Chinese liverwort Conocephalum conicum and six known compounds, 5,7-dihydroxycalamenene (6), 7-hydroxycalamenene (7), lunularin (8), riccardin C (9), marchantin C (10) and riccardin D (11) were isolated from Dumortiera hirsuta. Their structures were elucidated by extensive spectral analysis and chemical correlations. Compounds 1 and 8 showed moderate cytotoxicity against human HepG2 cells with IC50 4.5 microg/ml and 7.4 microg/ml, respectively, while compound 8 also showed antimicrobacterial activity against Pseudomonas aeruginosa with minimum inhibitory concentration at 64 microg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bibenzyls / chemistry*
  • Bibenzyls / isolation & purification*
  • China
  • Hepatophyta / chemistry*
  • Molecular Structure
  • Terpenes / chemistry*
  • Terpenes / isolation & purification*

Substances

  • Bibenzyls
  • Terpenes