Abstract
Recent reports suggest that hemopoietic stem cells with constitutional pericentric inversion of chromosome 9 [inv(9)] may be related to delayed engraftment or hemopoietic defect after stem cell transplantation (SCT). We conducted a retrospective study on five allogeneic SCT in which constitutional inv(9) was detected either in the donor or the recipient. The results showed that hematologic recovery was within the expected time range for all our patients. However, one patient exhibited decreasing blood counts between day +45 and +272 after transplantation, possibly due to protracted cytomegalovirus (CMV) infection and gansiclovir and imatinib treatment. Our findings suggest that constitutional inv(9) may not be associated with delayed hemopoietic recovery after SCT.
MeSH terms
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Adult
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Antiviral Agents / administration & dosage
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Benzamides
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Chromosome Inversion*
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Chromosomes, Human, Pair 9* / genetics
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Cytomegalovirus Infections / drug therapy
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Cytomegalovirus Infections / etiology
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Ganciclovir
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Hematologic Diseases / complications
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Hematologic Diseases / genetics
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Hematologic Diseases / therapy
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Hematopoiesis* / drug effects
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Hematopoiesis* / genetics
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Humans
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Imatinib Mesylate
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Male
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Piperazines / administration & dosage
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Protein Kinase Inhibitors / administration & dosage
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Pyrimidines / administration & dosage
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Recovery of Function* / drug effects
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Recovery of Function* / genetics
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Stem Cell Transplantation* / adverse effects
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Stem Cell Transplantation* / methods
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Time Factors
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Transplantation, Homologous
Substances
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Antiviral Agents
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Benzamides
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Piperazines
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Protein Kinase Inhibitors
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Pyrimidines
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Imatinib Mesylate
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Ganciclovir