Abstract
The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested in vitro. Both H oximes (HI-6, HLö-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase was low and did not reach the reactivating efficacy of trimedoxime and obidoxime. Thus, none of these compounds can be considered to be a broad-spectrum reactivator of nerve agent-inhibited acetylcholinesterase in spite of high potency to reactivate acetylcholinesterase inhibited by some nerve agents. More than one oxime may be necessary for the antidotal treatment of nerve agent-exposed individuals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / physiology*
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Animals
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Antidotes / pharmacology
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Brain / drug effects*
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Chemical Warfare Agents / pharmacology*
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Cholinesterase Inhibitors / pharmacology
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Cholinesterase Reactivators / pharmacology*
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Male
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Obidoxime Chloride / pharmacology
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Organophosphates / pharmacology
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Organothiophosphorus Compounds / pharmacology
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Oximes / pharmacology*
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Pralidoxime Compounds / pharmacology
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Pyridines / pharmacology
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Pyridinium Compounds / pharmacology
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Rats
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Rats, Wistar
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Trimedoxime / pharmacology
Substances
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Antidotes
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BI 6
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Chemical Warfare Agents
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Cholinesterase Inhibitors
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Cholinesterase Reactivators
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Organophosphates
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Organothiophosphorus Compounds
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Oximes
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Pralidoxime Compounds
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Pyridines
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Pyridinium Compounds
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HLo 7
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Obidoxime Chloride
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Trimedoxime
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VX
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Acetylcholinesterase
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asoxime chloride
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pralidoxime
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tabun