Abstract
We have investigated separate as well as combined influence of IL-1beta TaqI, IL-1ra VNTR and CTLA-4 + 49 A/G polymorphisms on susceptibility, clinical course and progression of MS in 162 Serbian patients. We found significant independent relative risk for MS susceptibility in noncarriers of IL-1ra allele 2 (OR = 2.2, CI = 1.3-3.7, p = 0.003) and CTLA-4 + 49 AA genotype (OR = 2.0, CI = 1.2-3.5, p = 0.01) as well as their combined effect (OR = 4.4, CI = 2.0-9.7, p = 0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antigens, CD
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Antigens, Differentiation / genetics*
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CTLA-4 Antigen
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DNA Mutational Analysis
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Female
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Gene Frequency / genetics
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Haplotypes / genetics
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Humans
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1 / genetics*
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Male
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Middle Aged
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Minisatellite Repeats / genetics
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Multiple Sclerosis / genetics*
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Multiple Sclerosis / immunology*
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Multiple Sclerosis / physiopathology
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Polymorphism, Genetic / genetics*
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Sialoglycoproteins / genetics*
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Yugoslavia
Substances
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Antigens, CD
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Antigens, Differentiation
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CTLA-4 Antigen
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CTLA4 protein, human
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Genetic Markers
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IL1RN protein, human
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1
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Sialoglycoproteins