Abstract
Seven genetically related Proteus mirabilis clinical isolates from a hospital in Thessaloniki, Greece, exhibited decreased susceptibility to imipenem and carried a bla(VIM-1) metallo-beta-lactamase gene. PCR mapping revealed that bla(VIM-1) was part of a class 1 integron that was probably located in the chromosome and also included the aacA7, dhfr and aadA genes. This is the first description of the bla(VIM-1) metallo-beta-lactamase gene in P. mirabilis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Carbapenems / therapeutic use
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Cross Infection / drug therapy
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Cross Infection / microbiology
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Humans
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Imipenem / therapeutic use
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Microbial Sensitivity Tests / methods
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Proteus Infections / drug therapy
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Proteus mirabilis / drug effects
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Proteus mirabilis / genetics*
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Proteus mirabilis / isolation & purification
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Carbapenems
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Imipenem
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VIM-1 metallo-beta-lactamase
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beta-Lactamases