Abstract
High levels of interspecies conservation characterise all signal transduction cascades and demonstrate the significance of these pathways over evolutionary time. Here, we review advances in the field of JAK/STAT signalling, focusing on recent developments in Drosophila. In particular, recent results from genetic and genome-wide RNAi screens, as well as studies into the developmental roles played by this pathway, highlight striking levels of physical and functional conservation in processes such as cellular proliferation, immune responses and stem cell maintenance. These insights underscore the value of model organisms for improving our understanding of this human disease-relevant pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Drosophila melanogaster / anatomy & histology
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Drosophila melanogaster / embryology
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Drosophila melanogaster / growth & development
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Drosophila melanogaster / physiology*
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Humans
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Janus Kinases
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Protein Inhibitors of Activated STAT / genetics
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Protein Inhibitors of Activated STAT / metabolism
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / metabolism*
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STAT Transcription Factors / genetics
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STAT Transcription Factors / metabolism*
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Signal Transduction / physiology*
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Stem Cells / cytology
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Stem Cells / physiology
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Suppressor of Cytokine Signaling Proteins / genetics
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Suppressor of Cytokine Signaling Proteins / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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BRWD3 protein, human
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DNA-Binding Proteins
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Drosophila Proteins
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Ken protein, Drosophila
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Protein Inhibitors of Activated STAT
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STAT Transcription Factors
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Stat92E protein, Drosophila
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Su(var)2-10 protein, Drosophila
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Suppressor of Cytokine Signaling Proteins
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Transcription Factors
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Protein-Tyrosine Kinases
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Janus Kinases
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hop protein, Drosophila