Abstract
Helicobacter pylori colonizes the human gastric mucosa, causing inflammation that leads to atrophic gastritis, and it can cause peptic ulcer and gastric cancer. We show that polyphenol administration to mice experimentally infected by H. pylori or treated with VacA toxin can limit gastric epithelium damage, an effect that may be linked to VacA inhibition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Proteins / administration & dosage*
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Colony Count, Microbial
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Flavonoids / administration & dosage
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Flavonoids / therapeutic use*
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Gastric Mucosa / microbiology
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Gastritis / drug therapy*
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Gastritis / microbiology
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Helicobacter Infections / drug therapy*
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Helicobacter Infections / microbiology
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Helicobacter pylori / drug effects
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Helicobacter pylori / growth & development
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Humans
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Mice
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Mice, Inbred BALB C
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Phenols / administration & dosage
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Phenols / therapeutic use*
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Polyphenols
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Specific Pathogen-Free Organisms
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Tannins / administration & dosage
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Tannins / therapeutic use
Substances
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Bacterial Proteins
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Flavonoids
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Phenols
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Polyphenols
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Tannins
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VacA protein, Helicobacter pylori