Abstract
A trinuclear 3N-chelated monofunctional platinum complex, [Pt3(HPTAB)Cl3](ClO4)3 (HPTAB = N,N,N',N',N'',N''-hexakis(2-pyridylmethyl)-1,3,5-tris(aminomethyl)benzene), has been structurally characterized, which binds to DNA and demonstrates much higher potency against the murine leukemia cell line (P-388) and the human nonsmall-cell lung cancer cell line (A-549) than cisplatin.
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Chelating Agents / chemistry*
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Chelating Agents / toxicity
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Circular Dichroism
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Crystallography, X-Ray
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DNA / chemistry*
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Structure
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Nitrogen / chemistry*
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Plasmids / chemistry
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Platinum Compounds / chemistry*
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Platinum Compounds / toxicity*
Substances
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Chelating Agents
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Platinum Compounds
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DNA
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Nitrogen