ERP/CSD indices of impaired verbal working memory subprocesses in schizophrenia

Psychophysiology. 2006 May;43(3):237-52. doi: 10.1111/j.1469-8986.2006.00398.x.

Abstract

To disentangle subprocesses of verbal working memory deficits in schizophrenia, long EEG epochs (>10 s) were recorded from 13 patients and 17 healthy adults during a visual word serial position test. ERP generator patterns were summarized by temporal PCA from reference-free current source density (CSD) waveforms to sharpen 31-channel topographies. Patients showed poorer performance and reduced left inferior parietotemporal P3 source. Build-up of mid-frontal negative slow wave (SW) in controls during item encoding, integration, and active maintenance was absent in patients, whereas a sustained mid-frontal SW sink during the retention interval was comparable across groups. Mid-frontal SW sinks (encoding and retention periods) and posterior SW sinks and sources (encoding only) were related to performance in controls only. Data suggest disturbed processes in a frontal-parietotemporal network in schizophrenia, affecting encoding and early item storage.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Electroencephalography
  • Evoked Potentials / physiology*
  • Female
  • Humans
  • Male
  • Memory, Short-Term / physiology*
  • Principal Component Analysis
  • Schizophrenic Psychology*