Abstract
A structure-activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D(1)-selective and D(2)-selective compounds can be obtained.
MeSH terms
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Clozapine / chemical synthesis
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Clozapine / chemistry*
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Clozapine / pharmacology
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Dopamine Antagonists / chemical synthesis
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Dopamine Antagonists / chemistry
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Dopamine Antagonists / pharmacology
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Dopamine D2 Receptor Antagonists
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Molecular Structure
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Receptors, Dopamine D1 / antagonists & inhibitors
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Receptors, Dopamine D1 / metabolism
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Receptors, Dopamine D2 / metabolism
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Structure-Activity Relationship
Substances
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Dopamine Antagonists
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Dopamine D2 Receptor Antagonists
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Clozapine