Traumatic dissociation, epileptic-like phenomena, and schizophrenia

Neuro Endocrinol Lett. 2006 Jun;27(3):321-6.

Abstract

Objectives: According to recent evidence, trauma and stress are important etiological factors in pathogenesis of schizophrenia. However, the hypothetical influence of traumatic stress on epileptic-like (or kindling) phenomena in schizophrenia is at this time unclear.

Methods: In order to discover the influence of trauma, 82 patients with a diagnosis of paranoid schizophrenia and 50 healthy controls were assessed for symptoms of dissociation, traumatic stress and psycho-sensory symptoms of epileptic origin.

Results: We have found significant traumatization and dissociation in patients who met the cut-off score for psychosensory epileptic-like symptoms and also significant correlations among these measures have been found.

Conclusions: These data suggest a certain role of epileptic-like phenomena in dissociative states in schizophrenia and are in accordance with rare intracranial EEG findings which suggest a certain role of epileptiform events in schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dissociative Disorders / complications
  • Dissociative Disorders / diagnosis*
  • Dissociative Disorders / psychology
  • Epilepsy / complications
  • Epilepsy / diagnosis*
  • Epilepsy / physiopathology
  • Female
  • Humans
  • Kindling, Neurologic / physiology
  • Male
  • Schizophrenia / complications*
  • Schizophrenia / physiopathology
  • Schizophrenic Psychology
  • Stress Disorders, Post-Traumatic / complications
  • Stress Disorders, Post-Traumatic / diagnosis*
  • Stress Disorders, Post-Traumatic / physiopathology
  • Stress, Psychological / complications
  • Stress, Psychological / diagnosis*
  • Stress, Psychological / physiopathology