Abstract
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Line
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Chromosome Banding
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Chromosomes, Human, Pair 10*
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Chromosomes, Human, Pair 7
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DNA, Neoplasm / genetics
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DNA, Neoplasm / isolation & purification
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DNA-Binding Proteins / genetics
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Genes, Homeobox*
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Homeodomain Proteins*
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Humans
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Introns
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Mice
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Molecular Sequence Data
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Oncogene Proteins / genetics*
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Oncogenes*
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Proto-Oncogene Proteins
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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T-Lymphocytes / physiology*
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Translocation, Genetic
Substances
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DNA, Neoplasm
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DNA-Binding Proteins
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Homeodomain Proteins
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Oncogene Proteins
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Proto-Oncogene Proteins
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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Tlx1 protein, mouse
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TLX1 protein, human
Associated data
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GENBANK/M75952
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GENBANK/M75953