Abstract
It has been known that phosphate homeostasis is mainly regulated by parathyroid hormone and vitamin D. Fibroblast growth factor 23 (FGF23) has been identified as a novel factor that regulates vitamin D and phosphate metabolism. Genetic defect of FGF23 in mice revealed not only abnormal vitamin D and phosphate metabolism, but also premature aging-like phenotype that is quite similar to Klotho mice. Regulation of vitamin D and phosphate metabolism is closely related to aging processes as well as bone and mineral metabolism.
MeSH terms
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Aging / genetics*
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Aging, Premature / genetics
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Animals
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Bone and Bones / metabolism*
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Fibroblast Growth Factor-23
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Fibroblast Growth Factors / physiology*
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Forkhead Transcription Factors
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Glucuronidase / genetics
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Humans
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Insulin-Like Growth Factor I / physiology
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Klotho Proteins
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Mice
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Phosphates / metabolism*
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Phosphorus, Dietary / administration & dosage
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Signal Transduction / genetics
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Signal Transduction / physiology
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Vitamin D / adverse effects
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Vitamin D / metabolism
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Vitamin D / physiology*
Substances
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FGF23 protein, human
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Fgf23 protein, mouse
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Forkhead Transcription Factors
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Phosphates
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Phosphorus, Dietary
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Vitamin D
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Fibroblast Growth Factors
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Insulin-Like Growth Factor I
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Fibroblast Growth Factor-23
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Glucuronidase
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Klotho Proteins