Abstract
Levels of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (serotonin, 5-HT) and their metabolites, and the activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and monoamine oxidase A and B (MAO-A and MAO-B) have been determined in the rat posterior thalamus after enucleation during postnatal development. DA and 5-HT turnover rate have been measured as 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) accumulation rates after central decarboxylase inhibition by 3-hydroxybenzylhydrazine (NSD-1015). The major changes were an increase in noradrenergic and serotoninergic metabolism in enucleated animals compared with control animals. A decrease of the MAO-A to MAO-B ratio during postnatal development was found.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Hydroxytryptophan / metabolism
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Aging / metabolism
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Animals
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Animals, Newborn / physiology*
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Aromatic Amino Acid Decarboxylase Inhibitors
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Aromatic-L-Amino-Acid Decarboxylases / metabolism
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Biogenic Monoamines / metabolism*
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Dihydroxyphenylalanine / metabolism
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Dopamine / metabolism
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Eye Enucleation*
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Hydrazines / pharmacology
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Male
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Monoamine Oxidase / metabolism
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Norepinephrine / metabolism
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism
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Thalamus / growth & development*
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Thalamus / metabolism
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Tryptophan Hydroxylase / metabolism
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Aromatic Amino Acid Decarboxylase Inhibitors
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Biogenic Monoamines
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Hydrazines
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Serotonin
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Dihydroxyphenylalanine
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3-hydroxybenzylhydrazine
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5-Hydroxytryptophan
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Tyrosine 3-Monooxygenase
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Tryptophan Hydroxylase
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Monoamine Oxidase
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Aromatic-L-Amino-Acid Decarboxylases
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Dopamine
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Norepinephrine