Bringing order to early B cell chaos

J Exp Med. 2006 Jun 12;203(6):1389. doi: 10.1084/jem.2036fta.

Abstract

In the early 1990s, Richard (Randy) Hardy and colleagues divided B cell precursors into subpopulations--the Hardy fractions--based on the cells' expression of various cell surface proteins. This classification helped lay the groundwork for our present-day understanding of the molecular events that control early B cell development.

Publication types

  • Historical Article

MeSH terms

  • B-Lymphocytes / immunology
  • B-Lymphocytes / physiology*
  • History, 20th Century
  • Humans
  • Stem Cells / cytology
  • Stem Cells / immunology
  • Stem Cells / physiology*