Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds

Christiana Hadjipavlou; Ioannis K Kostakis; Nicole Pouli; Panagiotis Marakos; Harris Pratsinis; Dimitris Kletsas

doi:10.1016/j.bmcl.2006.06.074

Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4822-5. doi: 10.1016/j.bmcl.2006.06.074. Epub 2006 Jul 7.

Authors

Christiana Hadjipavlou¹, Ioannis K Kostakis, Nicole Pouli, Panagiotis Marakos, Harris Pratsinis, Dimitris Kletsas

Affiliation

¹ Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.

PMID: 16824751
DOI: 10.1016/j.bmcl.2006.06.074

Abstract

A series of novel aminosubstituted benzopyranoisoindoles possessing structural analogy to an active nitracrine metabolite are reported. The compounds exhibited interesting cytotoxic activity against a panel of cell lines, which was maximized by the presence of both 1-dialkylaminoethyl and 3-nitro substituents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
Cell Proliferation / drug effects
DNA / genetics
Humans
Indoles / chemical synthesis
Indoles / chemistry*
Indoles / classification
Indoles / toxicity*
Molecular Structure
Nitracrine / chemistry
Nitracrine / metabolism
Structure-Activity Relationship
Xanthenes / chemistry
Xanthenes / toxicity

Substances

Indoles
Xanthenes
Nitracrine
DNA