Synthesis and antiproliferative activity of novel sugiol beta-amino alcohol analogs

I Córdova; L G León; F León; L San Andrés; J G Luis; J M Padrón

doi:10.1016/j.ejmech.2006.06.001

Synthesis and antiproliferative activity of novel sugiol beta-amino alcohol analogs

Eur J Med Chem. 2006 Nov;41(11):1327-32. doi: 10.1016/j.ejmech.2006.06.001. Epub 2006 Jul 7.

Authors

I Córdova¹, L G León, F León, L San Andrés, J G Luis, J M Padrón

Affiliation

¹ Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, La Laguna, Spain.

PMID: 16828933
DOI: 10.1016/j.ejmech.2006.06.001

Abstract

A series of beta-amino alcohol analogs of sugiol were synthesized in a straightforward manner. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573 and WiDr. The most potent analogs induced considerably growth inhibition in the range 1.5-6.7 microM. The results showed that beta-amino alcohol analogs are more potent than the parent compound. In addition, the derivatives with secondary amine fragments showed more active than those bearing tertiary amines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Alcohols / chemical synthesis*
Amino Alcohols / chemistry
Amino Alcohols / pharmacology*
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Diterpenes / chemical synthesis*
Diterpenes / chemistry
Diterpenes / pharmacology*
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Spectrophotometry, Infrared
Structure-Activity Relationship

Substances

Amino Alcohols
Antineoplastic Agents
Diterpenes
sugiol