Objective: To investigate the etiologic factors of globozoospermia.
Methods: Routine semen analysis, sperm DNA special staining and chromosomal karyotype detection of peripherical blood lymphocytes were performed in a globozoospermia patient.
Results: Round-headed spermatozoa were lack of acrosome and the acrosin activity was low. Meanwhile, there was an additional band located in the Y chromosomal short arm.
Conclusion: Lack of acrosome, low acrosin activity and abnormality of chromosome may be the main reasons for globozoospermia.