First total synthesis of (+/-)-3-aza-11-oxa-1,3,5(10)-trieno steroids

Steroids. 2006 Oct;71(10):886-94. doi: 10.1016/j.steroids.2006.06.003. Epub 2006 Jul 10.

Abstract

We set out to describe a new and versatile method for preparing 3-aza-11-oxa-1,3,5(10)-trieno steroids via an intramolecular Diels-Alder cycloaddition of o-quinodimethanes as the key step. The characteristic 1H and 13C NMR spectroscopic features of the synthesized compounds are reported.

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Steroids / chemical synthesis*

Substances

  • Steroids