Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa

David Montalvo; Philippe Amade; Corinne Funel-Le Bon; Rogelio Fernández; Fernando Reyes

doi:10.1080/14786410500183274

Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa

Nat Prod Res. 2006 May 20;20(6):548-52. doi: 10.1080/14786410500183274.

Authors

David Montalvo¹, Philippe Amade, Corinne Funel-Le Bon, Rogelio Fernández, Fernando Reyes

Affiliation

¹ Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain.

PMID: 16835086
DOI: 10.1080/14786410500183274

Abstract

A new cembranolide, acerolide (1) together with the known compound pseudopterolide (2) were isolated from the 2-propanol extract of the soft coral Pseudopterogorgia acerosa. The structure of 1 was determined on the basis of detailed spectroscopic analysis. Compound 1 showed moderate in vitro cytotoxicity against a panel of 14 tumor cell lines.

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Drug Screening Assays, Antitumor
HeLa Cells
Humans
K562 Cells
Martinique
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Antineoplastic Agents
Diterpenes