Abstract
A novel antigen preparation--the synthetic C6 peptide, a conserved portion of the variable VlsE antigens of Borrelia burgdorferi--has been evaluated for serodiagnosis of Lyme borreliosis (LB) by an ELISA procedure. Serum specimens were from early and late LB patients, all resident in an endemic area in north-eastern Italy. The specificity of the test approached the 100% and sensitivity was in the order of 63% (early LB) and 100% (late LB); this performance is superior to the preceding generation of Lyme disease tests.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / blood*
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Antigens, Bacterial / chemistry
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Bacterial Proteins / chemistry
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Borrelia burgdorferi / immunology*
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Endemic Diseases
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Enzyme-Linked Immunosorbent Assay / methods
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Humans
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Immunoblotting / methods
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Italy / epidemiology
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Lipoproteins / chemistry
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Lyme Disease / blood
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Lyme Disease / diagnosis*
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Lyme Disease / epidemiology
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Sensitivity and Specificity
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Proteins
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Lipoproteins
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VlsE protein, Borrelia burgdorferi