In search of an optimum dose escalation for narrowband UVB phototherapy: is it time to quit 20% increments?

J Am Acad Dermatol. 2006 Aug;55(2):269-71. doi: 10.1016/j.jaad.2006.04.019.

Abstract

Objectives: Our aim was to compare 20% with 10% to 5% incremental regimens in narrowband UVB phototherapy.

Study patients: The study included patients with psoriasis (N = 191) with Fitzpatrick skin phototypes II and III.

Results: Occurrence of erythema as well as maximum and cumulative doses were higher with 20% escalations, whereas response rates and time to response did not significantly differ.

Limitations: The study was limited by its retrospective nature.

Conclusion: A 5% or 10% incremental regimen may have similar therapeutic efficacy.

MeSH terms

  • Erythema / etiology
  • Female
  • Humans
  • Male
  • Phototherapy / adverse effects
  • Phototherapy / methods*
  • Psoriasis / therapy*
  • Retrospective Studies
  • Treatment Outcome
  • Ultraviolet Rays*