Islet cell tumor

Ultrastruct Pathol. 1991 Jul-Oct;15(4-5):579-84. doi: 10.3109/01913129109016266.

Abstract

A case of islet cell tumor occurring in a patient with the multiple endocrine neoplasia type I syndrome is reported. Immunostaining for insulin was strongly positive in the tumor cells. Numerous dense-core granules of endocrine caliber were identified ultrastructurally. Morphometric analysis of the secretory granules in 20 islet cell tumors gave a granule size of 182 +/- 52 nm (mean +/- standard deviation).

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Islet Cell / chemistry
  • Adenoma, Islet Cell / pathology*
  • Adenoma, Islet Cell / ultrastructure
  • Adult
  • Cytoplasmic Granules / ultrastructure
  • Female
  • Glucagon / analysis
  • Humans
  • Insulin / analysis
  • Microscopy, Electron
  • Multiple Endocrine Neoplasia / chemistry
  • Multiple Endocrine Neoplasia / pathology*
  • Multiple Endocrine Neoplasia / ultrastructure
  • Pancreatic Neoplasms / chemistry
  • Pancreatic Neoplasms / pathology*
  • Pancreatic Neoplasms / ultrastructure
  • Pancreatic Polypeptide / analysis

Substances

  • Insulin
  • Pancreatic Polypeptide
  • Glucagon