PrP amyloid plaques in Creutzfeldt-Jakob disease of short duration: immunohistochemical studies of 5 cases from Poland

Eur J Epidemiol. 1991 Sep;7(5):505-10. doi: 10.1007/BF00143130.

Abstract

We report here PrP-immunohistochemistry performed on brains from CJD cases from Poland. Only one of five definitive CJD cases exhibited typical PrP-immunoreactive kuru-like plaques and this was case of a short duration. We thus confirm the low frequency of PrP plaques in CJD of Eastern and Central European origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brain / metabolism*
  • Creutzfeldt-Jakob Syndrome / epidemiology
  • Creutzfeldt-Jakob Syndrome / metabolism*
  • Female
  • Gerstmann-Straussler-Scheinker Disease / metabolism
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Poland / epidemiology
  • PrPSc Proteins
  • Prions / metabolism*

Substances

  • PrPSc Proteins
  • Prions