Abstract
The effect of interleukin-1beta on presynaptic NMDA receptors was evaluated by studying NMDA-induced 45Ca2+ uptake by synaptosomes from rat brain cortex. Interleukin-1beta inhibited 45Ca2+ uptake by synaptosomes. Our results indicate that interleukin-1beta modulates presynaptic NMDA receptors and is probably involved in the regulation of synaptic transmission in the central nervous system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / metabolism*
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Calcium Radioisotopes / pharmacokinetics*
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Cerebral Cortex / metabolism*
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Interleukin-1 / metabolism
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Interleukin-1 / physiology*
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N-Methylaspartate / pharmacology*
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Rats
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Rats, Wistar
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Receptors, N-Methyl-D-Aspartate / metabolism*
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Synaptic Transmission / drug effects
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Synaptosomes / metabolism
Substances
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Calcium Radioisotopes
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Interleukin-1
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Receptors, N-Methyl-D-Aspartate
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N-Methylaspartate