Abstract
Triglycerides are stored in intracellular lipid droplets in mammalian cells. Current evidences suggest that the intracellular lipid droplets are active participants in a variety of metabolic processes, and thus are considered as functional organelles in cells. The lipid droplet is composed of a triglyceride core surrounded by a phospholipid monolayer in which several proteins are embedded. Four of these proteins belong to a family of structurally related PAT protein, which includes perilipin, ADRP, TIP47 and S3-12. In this review, we summarize the functions of these proteins in the modulation of lipolysis and lipid droplets formation.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adipocytes / diagnostic imaging
-
Adipocytes / metabolism
-
Animals
-
Carrier Proteins
-
DNA-Binding Proteins / physiology*
-
Endoplasmic Reticulum / metabolism
-
Humans
-
Intracellular Signaling Peptides and Proteins / physiology*
-
Lipid Metabolism / physiology*
-
Membrane Proteins / physiology*
-
Mice
-
Perilipin-1
-
Perilipin-2
-
Perilipin-3
-
Perilipin-4
-
Phosphoproteins / physiology*
-
Pregnancy Proteins / physiology*
-
Triglycerides / metabolism*
-
Ultrasonography
-
Vesicular Transport Proteins
Substances
-
Carrier Proteins
-
DNA-Binding Proteins
-
Intracellular Signaling Peptides and Proteins
-
Membrane Proteins
-
PLIN2 protein, human
-
PLIN3 protein, human
-
Perilipin-1
-
Perilipin-2
-
Perilipin-3
-
Perilipin-4
-
Phosphoproteins
-
Plin2 protein, mouse
-
Plin4 protein, mouse
-
Pregnancy Proteins
-
Triglycerides
-
Vesicular Transport Proteins