Abstract
A series of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles were synthesized by one-pot reaction from o-phenylenediamine, 2-mercaptoacetic acid and a variety of aromatic aldehydes. All compounds obtained were evaluated for antiviral activity against human immunodeficiency virus (HIV). Compounds 4g, 4i, 4j, 4l and 4q exhibit reproducible in vitro anti-HIV activity.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / chemistry
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Benzimidazoles / pharmacology
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / microbiology
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Cell Line
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Cytopathogenic Effect, Viral / drug effects
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HIV / drug effects*
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Humans
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry
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Thiazoles / pharmacology
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Zalcitabine / pharmacology
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Zidovudine / pharmacology
Substances
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Antiviral Agents
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Benzimidazoles
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Thiazoles
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Zidovudine
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Zalcitabine