Abstract
The interaction between FLFQPQRFamide and alpha 2-adrenergic spinal antinociception was examined in an electrophysiological study in the intact anaesthetised rat. The inhibition of C fibre-evoked neuronal responses by the selective alpha 2-adrenergic agonist dexmedetomidine was significantly reduced by intrathecal FLFQPQRFamide pretreatment. The results suggest a modulatory role of FLFQPQRFamide in spinal alpha 2-adrenergic antinociception.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Agonists / pharmacology*
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Amino Acid Sequence
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Analgesics / pharmacology*
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Animals
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Electric Stimulation
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Imidazoles / pharmacology*
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Medetomidine
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Molecular Sequence Data
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Nerve Fibers / drug effects
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Oligopeptides / physiology*
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Rats
Substances
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Adrenergic alpha-Agonists
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Analgesics
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Imidazoles
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Oligopeptides
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phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
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Medetomidine