Subtotal hepatectomy following neoadjuvant chemotherapy for a previously unresectable hepatocellular carcinoma

J Hepatobiliary Pancreat Surg. 2006;13(4):347-50. doi: 10.1007/s00534-005-1087-8.

Abstract

An awareness of variant hepatic vascular anatomy provides vital information in the preoperative evaluation of patients with hepatocellular carcinoma. The authors present a patient with unresectable hepatocellular carcinoma who responded to combination systemic and regional chemotherapy. Because of the presence of an enlarged inferior right hepatic vein, the patient subsequently underwent successful subtotal hepatectomy with resection of all three main hepatic veins. This case illustrates that the combination of innovative neoadjuvant chemotherapy and well-planned surgical approaches may benefit a small number of patients previously deemed unresectable.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Breast Neoplasms / surgery
  • Carcinoma, Ductal / surgery
  • Carcinoma, Hepatocellular / drug therapy
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / surgery*
  • Chemotherapy, Adjuvant
  • Cisplatin / therapeutic use
  • Doxorubicin / therapeutic use
  • Female
  • Fluorouracil / therapeutic use
  • Hepatectomy / methods*
  • Hepatic Veins / diagnostic imaging
  • Hepatic Veins / pathology
  • Hepatic Veins / surgery
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery*
  • Liver Neoplasms / therapy
  • Middle Aged
  • Neoadjuvant Therapy*
  • Neoplasm Invasiveness
  • Neoplasms, Second Primary / surgery
  • Recombinant Proteins
  • Tomography, X-Ray Computed

Substances

  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Doxorubicin
  • Cisplatin
  • Fluorouracil

Supplementary concepts

  • PIAF regimen