Abstract
Staphyloxanthin is a membrane-bound carotenoid of Staphylococcus aureus. Here we studied the interaction of staphyloxanthin with reactive oxygen substances (ROS) and showed by comparative analysis of the wild type (WT) and an isogenic crtM mutant that the WT is more resistant to hydrogen peroxide, superoxide radical, hydroxyl radical, hypochloride, and neutrophil killing.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Colony Count, Microbial
-
Culture Media
-
Heat-Shock Response
-
Mutation
-
Oxidants / pharmacology*
-
Oxidative Stress / physiology*
-
Staphylococcus aureus / drug effects*
-
Staphylococcus aureus / genetics
-
Staphylococcus aureus / growth & development
-
Staphylococcus aureus / physiology*
-
Xanthophylls / genetics
-
Xanthophylls / metabolism*
Substances
-
Culture Media
-
Oxidants
-
Xanthophylls
-
staphyloxanthin