Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia

Pediatr Blood Cancer. 2008 Mar;50(3):636-9. doi: 10.1002/pbc.21002.

Abstract

Secondary malignancies are an important cause of morbidity and mortality in childhood cancer survivors. Salivary gland tumors account for about 6% of the second cancers. The majority of these are mucoepidermoid carcinomas (MEC) of the parotid gland. We report the clinical and pathological features of a rarer histological type, acinic cell carcinoma (ACC), in a childhood acute lymphoblastic leukemia (ALL) survivor. The behavior of secondary ACC appears similar to primary tumor and similar treatment may be adopted. Early recognition and complete resection is important for achieving a good outcome. Careful monitoring for recurrence or a third malignancy is needed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenoma, Sweat Gland / etiology
  • Adenoma, Sweat Gland / surgery
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Asparaginase / administration & dosage
  • Asparaginase / adverse effects
  • Carcinoma, Acinar Cell / chemically induced
  • Carcinoma, Acinar Cell / etiology*
  • Carcinoma, Acinar Cell / radiotherapy
  • Carcinoma, Acinar Cell / surgery
  • Child, Preschool
  • Combined Modality Therapy / adverse effects
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects
  • Cytarabine / administration & dosage
  • Cytarabine / adverse effects
  • Daunorubicin / administration & dosage
  • Daunorubicin / adverse effects
  • Epirubicin / administration & dosage
  • Epirubicin / adverse effects
  • Etoposide / administration & dosage
  • Etoposide / adverse effects
  • Follow-Up Studies
  • Humans
  • Male
  • Mercaptopurine / administration & dosage
  • Mercaptopurine / adverse effects
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects
  • Neoplasms, Radiation-Induced / etiology*
  • Neoplasms, Radiation-Induced / radiotherapy
  • Neoplasms, Radiation-Induced / surgery
  • Neoplasms, Second Primary / chemically induced
  • Neoplasms, Second Primary / etiology*
  • Neoplasms, Second Primary / radiotherapy
  • Neoplasms, Second Primary / surgery
  • Parotid Neoplasms / chemically induced
  • Parotid Neoplasms / etiology*
  • Parotid Neoplasms / radiotherapy
  • Parotid Neoplasms / surgery
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Prednisolone / administration & dosage
  • Prednisolone / adverse effects
  • Recurrence
  • Remission Induction
  • Survivors
  • Sweat Gland Neoplasms / etiology
  • Sweat Gland Neoplasms / surgery
  • Vincristine / administration & dosage
  • Vincristine / adverse effects
  • Whole-Body Irradiation / adverse effects*

Substances

  • Cytarabine
  • Epirubicin
  • Vincristine
  • Etoposide
  • Cyclophosphamide
  • Prednisolone
  • Mercaptopurine
  • Asparaginase
  • Methotrexate
  • Daunorubicin

Supplementary concepts

  • UKALL X protocol