Abstract
Betaxolol, a beta 1-selective antagonist, produced marked improvement in eight patients with neuroleptic-induced akathisia. No further improvement was seen with subsequent propranolol treatment. These findings, along with the results of prior studies of betaxolol and metoprolol, suggest that blockade of central beta 1-receptors may be sufficient for efficacy in akathisia.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Akathisia, Drug-Induced*
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use
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Betaxolol / therapeutic use*
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Drug Administration Schedule
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Humans
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Middle Aged
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Neurologic Examination
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Propranolol / therapeutic use
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Psychomotor Agitation / drug therapy*
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Psychotic Disorders / drug therapy*
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Psychotic Disorders / psychology*
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*
Substances
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Antipsychotic Agents
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Propranolol
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Betaxolol